Mennonite Mission Network involvement in Argentina has two distinct foci: mission with the Iglesia Evangélica Menonita Argentina (IEMA—Argentina Mennonite Church), and with the Mennonite team in the Chaco. Mission workers from the former Mennonite Board of Missions (MBM) arrived in Argentina in 1917.

The development of the IEMA grew from this early mission work, and today, Mission Network partners with the IEMA in their leadership development and church-planting mission programs, including three formal regional partnerships. The IEMA has organized their regional mission programs in a Red de Misiones Menonitas Argentinas (RMMA – Argentine Mennonite Missions Network).   

IEMA missionaries, who are also recognized as International Partnership Associates with Mennonite Mission Network, are from the: 1) Patagonia Mission Project (PMP): Miguel and Angela Bamonde in Sierra Grande; Andrés and Faviola Pesoba in Caleta Olivia; Damián and Marta Reyes in Chos Malal; César and Miriam Riquelme in Puerto Madryn; and Wanda Sieber and Marlene Dorigoni in Valdivia, Chile; and 2) Missionary Program of Northern Argentina (PROMINOA): Dany and Mabel Soto in Paso de los Libres, Corrientes; and Julio and Alicia Soto in Mercedes, Corrientes.

MBM mission work with indigenous people in Argentina's northern Chaco region began in 1943. Mennonite Mission Network encourages the indigenous churches in their development of leaders and in their unique style of worship and organization, as well as supporting Bible translation and leadership development work.

International Partnership Associates serving with the Mennonite team in the Chaco include Esteban and Susana González Zugasti in Resistencia, and Alfonsina and José Luis Oyanguren in Castelli.