Mennonite Central Committee began work in Botswana in the 1970s, providing schoolteachers and training in job skills. As a result of friendships with local African-Initiated Churches, Africa Inter-Mennonite Mission - with which Mennonite Mission Network is a partner - was invited to send Bible teachers.

Beginning in 1975, six Mennonite denominations have sent workers to Botswana. In addition to Bible teaching among African-Initiated Churches, these workers are involved in AIDS education and counseling, community development, youth ministry, friendship evangelism, teaching and issues related to families.